Declining Antibody Affinity Over Time After Human Vaccination With a Plasmodium falciparum Merozoite Vaccine Candidate

KEM Persson; JL Horton; L Kurtovic; JS Mccarthy; RF Anders; JG Beeson

Journal article

Declining Antibody Affinity Over Time After Human Vaccination With a Plasmodium falciparum Merozoite Vaccine Candidate

KEM Persson, JL Horton, L Kurtovic, JS Mccarthy, RF Anders, JG Beeson

Journal of Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2024

DOI: 10.1093/infdis/jiae259

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Abstract

Maintaining high-affinity antibodies after vaccination may be important for long-lasting immunity to malaria, but data on induction and kinetics of affinity is lacking. In a phase 1 malaria vaccine trial, antibody affinity increased following a second vaccination but declined substantially over 12 months, suggesting poor maintenance of high-affinity antibodies.

University of Melbourne Researchers

James McCarthy Author

James Beeson Author

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Awarded by Lunds Universitet

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council, Australia (grant numbers 1173046 and 1092789 to J. B.); and Avtal om Lakarutbildning och Forskning (Region Skane/Lund University to K. P.). Funding to pay the open access publication charges for this article was provided by Burnet Institute.